Funded Grants

SEED GRANT

Grantee: City of Hope
Project Lead: Qi Cui, PHD
Grant Title: Targeting non-coding RNA pseudouridine modification for glioblastoma therapy
Grant Type: UKF Seed Grant
Year Awarded: 2024
Amount: $50,000
Duration: 1 year

Summary: Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. It is believed that GBM stem cells (GSCs) confer the treatment resistance and tumor recurrence for GBM. In this study, we aim to define the role of pseudouridine modification of non-coding RNA in GBM with the aim to develop novel GBM therapies by targeting this pathway. Specifically, we will investigate the regulation of noncoding RNA pseudouridine modification on GSC growth and tumorigenesis and the underlying mechanisms in this study. If successful, this study will lay a foundation for novel therapeutic development for GBM by targeting RNA pseudouridine modification and its regulatory pathways.