Funded Grants

Grantee: Johns Hopkins University
Project Lead: Stavroula Sofou, PHD
Grant Title: Alpha-particle radiotherapy for glioblastoma
Program Area: Glioblastoma Treatment
Grant Type: UKF Seed Grant
Year Awarded: 2022
Amount: $50,000
Duration: 1 year

Summary: Glioblastoma is a type of brain cancer that remains incurable. Our strategy aims to enable uniform delivery of a cytotoxic agent (an alpha-particle emitter) in established glioblastoma tumors with minimum toxicities to the surrounding healthy brain. Our approach is aimed to be more effective in inhibiting brain tumor progression than currently available treatment methods. If successful, this strategy will represent a new paradigm in alpha-particle radiotherapy for glioblastomas, enabled by a nanoparticle platform with an excellent safety profile. The resulting therapeutic intervention will have the potential to extend remission, improve the quality of life and prolong survival of patients diagnosed with glioblastoma who endure surgery, combinations of therapeutics and radiotherapy but who have a poor prognosis with no other options.